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Early‐onset Hepatic Fibrosis in Lysinuric Protein Intolerance - Shinawi - 2011 - Journal of Pediatric Gastroenterology and Nutrition - Wiley Online Library

Unfortunately, various defects, such as oxidative stress and mitochondrial dysfunction, could hinder oocyte maturation (Li et al., 2023)

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Under certain physiological conditions first described in pregnancy (119, 120), specific proteases cleave IGFBP-3 into several proteolytic fragments of which each may retain immunoactivity and thus give rise to signals in an immunometric assay (121)

And typically they have short shelf life